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DNA repair diseases: what do they tell us about cancer and aging? Genet. Mol. Biol.
Menck,Carlos FM; Munford,Veridiana.
The discovery of DNA repair defects in human syndromes, initially in xeroderma pigmentosum (XP) but later in many others, led to striking observations on the association of molecular defects and patients' clinical phenotypes. For example, patients with syndromes resulting from defective nucleotide excision repair (NER) or translesion synthesis (TLS) present high levels of skin cancer in areas exposed to sunlight. However, some defects in NER also lead to more severe symptoms, such as developmental and neurological impairment and signs of premature aging. Skin cancer in XP patients is clearly associated with increased mutagenesis and genomic instability, reflecting the defective repair of DNA lesions. By analogy, more severe symptoms observed in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Xeroderma pigmentosum; Ultraviolet; DNA damage; Oxidative stress; DNA repair.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000200008
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Streetlights attract a broad array of beetle species Rev. Bras. entomol.
Medeiros,Bruno Augusto Souza de; Barghini,Alessandro; Vanin,Sergio Antonio.
ABSTRACT Light pollution on ecosystems is a growing concern, and knowledge about the effects of outdoor lighting on organisms is crucial to understand and mitigate impacts. Here we build up on a previous study to characterize the diversity of all beetles attracted to different commonly used streetlight set ups. We find that lights attract beetles from a broad taxonomic and ecological spectrum. Lights that attract a large number of insect individuals draw an equally high number of insect species. While there is some evidence for heterogeneity in the preference of beetle species to different kinds of light, all species are more attracted to some light radiating ultraviolet. The functional basis of this heterogeneity, however, is not clear. Our results...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lighting; Coleoptera; Light pollution; Insects; Ultraviolet.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262017000100074
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